Use and Important safety information

MARINOL® (dronabinol capsules, USP) is used for loss of appetite associated with weight loss in patients with AIDS.

MARINOL is also used to treat nausea and vomiting that is associated with cancer chemotherapy in patients who have not responded to standard treatments for nausea and vomiting.

Important Safety Information1
MARINOL should not be used if you are allergic to dronabinol or any of its ingredients, including marijuana and sesame oil.

KEEP THIS MEDICINE OUT OF THE REACH OF CHILDREN AND PETS. If a child puts a capsule in his or her mouth or swallows MARINOL, take the medicine away from the child and contact a poison control center or a doctor immediately. Do not let anyone else use your medication.

Do not drive a car, operate machinery, or engage in any hazardous activity until you know how this medication affects you and until you are sure you can perform such tasks safely.

While taking MARINOL, do not drink alcohol, smoke marijuana, or take other drugs that have an effect on the central nervous system, such as Valium® (diazepam), Librium® (chlordiazepoxide), Xanax® (alprazolam), Seconal® (secobarbital), Nembutal® (pentobarbital), or phenobarbital, because they can have a dangerous interaction. It is important to tell your doctor or pharmacist about all other prescription and non-prescription medicines you are taking, as MARINOL use may change the effect of these medicines.

Be sure to tell your doctor if you:

  • Had or have heart disease or cardiac disorders. MARINOL may cause low or high blood pressure, fainting, or a fast heart rate
  • Currently abuse or have a past history of drug or alcohol abuse
  • Have or had mental health problems (mania, depression, schizophrenia); MARINOL may make these illnesses worse
  • Have a history of seizure disorder or seizure-like activity. If you experience a seizure, seek medical attention immediately.
  • Are pregnant or nursing or become pregnant

If you become pregnant while taking MARINOL, stop using it until you have talked to your doctor.

MARINOL has not been studied in children and should be used with caution.

Caution is advised when using this drug in the elderly, because they may be more sensitive to the effects of the drug.

You may experience changes in mood or have other effects when first taking MARINOL. Be sure that there is a responsible person nearby when you first take MARINOL or when there is an adjustment in your dose.

Do not smoke marijuana while using MARINOL. This can cause an overdose.

Adverse effects include loss of memory, anxiety/nervousness, lack of motor coordination, confusion, depersonalization, dizziness, paranoid reaction, sleepiness, abnormal thinking, weakness, irregular or rapid heartbeat, facial flush, abdominal pain, nausea, and vomiting.


  1. MARINOL [package insert]. North Chicago, IL: AbbVie Inc.