Use and Important safety information

Use1

MARINOL® (dronabinol) is a prescription medicine used in adults to treat:

  • Loss of appetite in people with AIDS (acquired immune deficiency syndrome) who have lost weight.
  • Nausea and vomiting caused by anti-cancer medicine (chemotherapy) in people whose nausea and vomiting have not improved with usual anti-nausea medicines.

MARINOL is a controlled substance, which can be a target for people who abuse prescription medicines or street drugs. Keep your MARINOL in a safe place to protect it from theft.

Important Safety Information1

Do not take MARINOL if you had an allergic reaction to dronabinol or sesame oil. Signs and symptoms of an allergic reaction to dronabinol include: swelling of the lips, hives, a rash over your whole body, mouth sores, skin burning, flushing, and throat tightness.

MARINOL can cause serious side effects, including:

  • Worsening of mental (psychiatric) symptoms in people who have mania, depression, or schizophrenia. Tell your doctor if you have new or worsening mood symptoms, including symptoms of mania, depression, or schizophrenia.
  • Problems thinking clearly. Tell your doctor if you have trouble remembering things, concentrating, have increased sleepiness, or confusion.
  • Changes in blood pressure. Tell your doctor if you have signs or symptoms of changes in your blood pressure, including: headaches, vision problems, dizziness, feeling lightheaded, fainting, or a fast heartbeat.

Elderly people may have a greater risk of these effects of MARINOL.

MARINOL may cause other serious side effects:

  • Seizures. MARINOL may increase your risk of seizures. Stop taking MARINOL and call your doctor and get medical help right away if you have a seizure.
  • Drug and alcohol abuse. You may have an increased risk of abusing MARINOL if you have a history of drug or alcohol abuse or dependence, including marijuana. Tell your doctor if you develop increased irritability, nervousness, restlessness, or want more or higher doses of MARINOL.
  • Nausea, vomiting, or stomach-area (abdominal) pain. Tell your doctor if you have nausea, vomiting, or abdominal pain, or if these get worse with treatment.

Before taking MARINOL, tell your doctor about all of your medical conditions, including if you:

  • Have or had problems with your heart, drug abuse or dependence, alcohol abuse or dependence.
  • Have or had mental health problems including mania, depression, or schizophrenia.
  • Have or had a seizure or have a medical condition that may increase your risk of seizures.
  • Are pregnant or plan to become pregnant. MARINOL may harm your unborn baby. Avoid use of MARINOL if you are pregnant.
  • Are breastfeeding or plan to breastfeed. Do not breastfeed while taking MARINOL and for 9 days after your last dose.

Tell your doctor about all prescription and over-the-counter medicines, vitamins, and herbal supplements you take or have taken in the last 14 days. MARINOL and certain other medicines can affect each other, causing serious side effects.

Do not drive, operate machinery, or do other dangerous activities until you know how MARINOL affects you. When taken with other medicines that cause dizziness, confusion, and sleepiness, MARINOL can worsen these symptoms.

The most common side effects of MARINOL include: dizziness, feeling extremely happy (euphoria), overly suspicious or feeling people want to harm you (paranoid reaction), sleepiness, abnormal thoughts, stomach-area (abdominal) pain, nausea, or vomiting.

Reference:
  1. MARINOL [package insert]. North Chicago, IL: AbbVie Inc.