dosage and administration1

Appetite Stimulation in AIDS-Related Anorexia With Weight Loss:

  • Initially, 2.5 mg MARINOL Capsules should be administered orally twice daily (b.i.d.), before lunch and supper.
  • For patients unable to tolerate this 5 mg/day dosage of MARINOL Capsules, the dosage can be reduced to 2.5 mg/day, administered as a single dose in the evening or at bedtime.
  • If clinically indicated and in the absence of significant adverse effects, the dosage may be gradually increased to a maximum of 20 mg/day MARINOL Capsules, administered in divided oral doses.
  • Caution should be exercised in escalating the dosage of MARINOL Capsules because of the increased frequency of dose-related adverse experiences at higher dosages.

Clinical Trials Dosing

Appetite Stimulation in AIDS-Related Anorexia With Weight Loss:

The pharmacologic effects of MARINOL Capsules are dose-related and subject to considerable interpatient variability. Therefore, dosage individualization is critical in achieving the maximum benefit of MARINOL Capsules treatment.

In the clinical trials, the majority of patients were treated with 5 mg/day MARINOL Capsules, although the dosages ranged from 2.5 to 20 mg/day.

For an adult:

  • Begin with 2.5 mg before lunch and 2.5 mg before supper. If CNS symptoms (feeling high, dizziness, confusion, somnolence) do occur, they usually resolve in 1 to 3 days with continued dosage.
  • If CNS symptoms are severe or persistent, reduce the dose to 2.5 mg before supper. If symptoms continue to be a problem, taking the single dose in the evening or at bedtime may reduce their severity.
  • When adverse effects are absent or minimal and further therapeutic effect is desired, increase the dose to 2.5 mg before lunch and 5 mg before supper or 5 mg and 5 mg.
  • Although most patients respond to 2.5 mg twice daily, 10 mg twice daily has been tolerated in about half of the patients in appetite stimulation studies.
  • The pharmacologic effects of MARINOL Capsules are reversible upon treatment cessation.