dosage and administration1

Appetite Stimulation in AIDS-Related Anorexia With Weight Loss:

  • Initially, 2.5 mg MARINOL should be administered orally twice daily (b.i.d.), one hour before lunch and dinner.
  • In elderly patients or patients unable to tolerate MARINOL 2.5 mg twice daily, the dosage can be reduced to 2.5 mg/day, administered as a single dose one hour before dinner or at bedtine to reduce the risk of CNS symptoms..
  • Most patients respond to MARINOL 2.5 mg twice daily. The dose may be further increased to 5 mg one hour before lunch and 5 mg one hour before dinner as tolerated to achieve therapeutic effect.
  • Increase the dose gradually. Adverse reations are dose-related and psychiatric symptoms increase significantly at the maximum dosage of 10 mg twice daily

Clinical Trials Dosing

Appetite Stimulation in AIDS-Related Anorexia With Weight Loss:

The pharmacologic effects of MARINOL are dose-related and subject to considerable interpatient variability. Therefore, dosage individualization is critical in achieving the maximum benefit of MARINOL treatment.

In the clinical trials, the majority of patients were treated with 5 mg/day MARINOL, although the dosages ranged from 2.5 to 20 mg/day.

For an adult:

  • Begin with 2.5 mg one hour before lunch and 2.5 mg one hour before dinner. If CNS adverse reactions (feeling high, dizziness, confusion, somnolence) do occur, they usually resolve in 1 to 3 days with continued dosage.
  • If CNS adverse reactions are severe or persistent, reduce the dose to 2.5 mg in the evening or at bedtime.
  • Dosing later in the day may reduce the frequency of CNS adverse reactions. CNS adverse reactions are dose-related; therefore monitor patients and reduce the dosage as needed.
  • When adverse effects are absent or minimal and further therapeutic effect is desired, increase the dose to 2.5 mg one hour before lunch and 5 mg one hour before dinner.
  • The maximum dosage is 10 mg twice daily.